1,318 research outputs found
Dynamic acoustic field activated cell separation (DAFACS)
Advances in diagnostics, cell and stem cell technologies drive the development of application-specific tools
for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for highthroughput,
label-free, high recovery, cell and particle separation and isolation in regenerative medicine.
Here, we demonstrate a novel approach utilizing a dynamic acoustic field that is capable of separating an
arbitrary size range of cells. We first demonstrate the method for the separation of particles with different
diameters between 6 and 45 μm and secondly particles of different densities in a heterogeneous medium.
The dynamic acoustic field is then used to separate dorsal root ganglion cells. The shearless, label-free and
low damage characteristics make this method of manipulation particularly suited for biological applications.
Advantages of using a dynamic acoustic field for the separation of cells include its inherent safety and
biocompatibility, the possibility to operate over large distances (centimetres), high purity (ratio of particle
population, up to 100%), and high efficiency (ratio of separated particles over total number of particles to
separate, up to 100%)
Locking Local Oscillator Phase to the Atomic Phase via Weak Measurement
We propose a new method to reduce the frequency noise of a Local Oscillator
(LO) to the level of white phase noise by maintaining (not destroying by
projective measurement) the coherence of the ensemble pseudo-spin of atoms over
many measurement cycles. This scheme uses weak measurement to monitor the phase
in Ramsey method and repeat the cycle without initialization of phase and we
call, "atomic phase lock (APL)" in this paper. APL will achieve white phase
noise as long as the noise accumulated during dead time and the decoherence are
smaller than the measurement noise. A numerical simulation confirms that with
APL, Allan deviation is averaged down at a maximum rate that is proportional to
the inverse of total measurement time, tau^-1. In contrast, the current atomic
clocks that use projection measurement suppress the noise only down to the
level of white frequency, in which case Allan deviation scales as tau^-1/2.
Faraday rotation is one of the possible ways to realize weak measurement for
APL. We evaluate the strength of Faraday rotation with 171Yb+ ions trapped in a
linear rf-trap and discuss the performance of APL. The main source of the
decoherence is a spontaneous emission induced by the probe beam for Faraday
rotation measurement. One can repeat the Faraday rotation measurement until the
decoherence become comparable to the SNR of measurement. We estimate this
number of cycles to be ~100 cycles for a realistic experimental parameter.Comment: 18 pages, 7 figures, submitted to New Journal of Physic
Magneto-Optical Trap for Thulium Atoms
Thulium atoms are trapped in a magneto-optical trap using a strong transition
at 410 nm with a small branching ratio. We trap up to atoms at
a temperature of 0.8(2) mK after deceleration in a 40 cm long Zeeman slower.
Optical leaks from the cooling cycle influence the lifetime of atoms in the MOT
which varies between 0.3 -1.5 s in our experiments. The lower limit for the
leaking rate from the upper cooling level is measured to be 22(6) s. The
repumping laser transferring the atomic population out of the F=3 hyperfine
ground-state sublevel gives a 30% increase for the lifetime and the number of
atoms in the trap.Comment: 4 pages, 6 figure
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